Bioinformatics Research Scientist

Location Remote\-United States Category Computational Sciences Department Developmental Neurobiology Shift Weekday Day Position Type Full Time Scheduled Weekly Hours 40 Req \# JR7320 **Job Description** ------------------- The Bioinformatics Research Scientist is responsible for designing, developing, improving, modifying, and operating data analysis pipelines. Manages projects and coordinates other efforts related to analysis and infrastructure as directed. The Escoubas Laboratory, within the Center of Excellence in Neuro\-Oncology Sciences (CENOS) at St. Jude Children's Research Hospital, is seeking a highly motivated **Bioinformatics Research Scientist** to join our growing research team. CENOS fosters a collaborative and innovative scientific environment dedicated to advancing discoveries that improve outcomes for children with brain tumors. The Escoubas Lab investigates bidirectional communication between neurons and microglia through nucleic acid sensing pathways, with implications for neurodevelopment, neurological disease, and pediatric brain tumors. This position is ideal for an individual with a strong background in bioinformatics, computational biology, or systems biology who is passionate about applying advanced computational approaches to complex biological questions. The successful candidate will partner closely with the Principal Investigator and laboratory members to develop and implement robust analytical workflows for single\-cell and spatial omics datasets, neuronal activity analyses, and human genetic studies. This role offers an exciting opportunity to contribute to high\-impact research at the intersection of neuroscience, immunology, and pediatric cancer biology. The Bioinformatics Research Scientist will be expected to: * Develop, maintain, and optimize analytical pipelines for single\-cell RNA sequencing (scRNA\-seq), bulk RNA sequencing, spatial transcriptomics, spatial proteomics, and neuronal activity datasets, including multi\-electrode array (MEA) data. * Perform genome\-wide association study (GWAS) enrichment analyses and integrate multi\-omic datasets to investigate mechanisms relevant to neurodevelopment, neurological disorders, and pediatric brain tumors. * Collaborate closely with laboratory scientists to design analyses, interpret results, and generate publication\-quality data visualizations. * Develop reproducible computational workflows and implement best practices for data processing, quality control, statistical analysis, and data management. * Assist in onboarding and mentoring new laboratory members in computational tools, bioinformatics workflows, and data analysis methodologies. * Coordinate with St. Jude core facilities, including genomics, proteomics, and imaging platforms, to facilitate sample submissions, data acquisition, and data management. * Contribute to scientific manuscripts, grant applications, presentations, and other dissemination of research findings. * Work independently while