Sr. Director, Clinical Program Management

Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company developing cell therapies for patients suffering from autoimmune diseases. Guided by our core values, Stay True to Why, Collaborate to Accelerate, Lead with Clarity, Boldly Innovative, and Own the Outcome, we are committed to transforming the future of treatment for autoimmune disease. Join us at the forefront of cell therapy innovation and help redefine what’s possible.Title: Sr. Director, Clinical Program ManagementReports to: SVP, Clinical and Development OperationsLocation: Remote with up to 20% travelKyverna is seeking a highly strategic and clinically focused Sr. Director, Clinical Program Management to lead cross-functional development activities supporting cell therapy programs in autoimmune indications. This individual will partner closely with Clinical Development, Clinical Operations, Medical Affairs, Biometrics, Regulatory, Safety, Technical Operations, and external partners to drive execution of complex global clinical programs from early development through registrational studies and potential commercialization.ResponsibilitiesTranslate program strategy into integrated timelines, milestones, and deliverables, ensuring coordination across all contributing functionsProvide Project Management expertise and support to advance Kyverna’s novel engineered T cell therapy programsManage one or more highly complex R&D programs and/or high-profile partnershipsResults-oriented accountability for achievement of program timeline and deliverablesEffectively communicate with project team members, Senior Leadership Team, Functional Heads, and key stakeholdersTrack and monitor key milestones and decision points to drive delivery of project objectivesContribute to PMO LT to develop tools for project governance and program timelines, as well as the communication of program KPIs, risks and achievementsManage the interfaces between functional areas and ensure effective handoff and communication between department functions to execute on important project milestonesLead cross-functional program management activities supporting autoimmune clinical development programs.Develop and maintain integrated clinical development plans, timelines, milestones, budgets, and risk management strategies across multiple functional areas.Drive execution and alignment across Clinical Development, Clinical Operations, Medical Affairs, Biometrics, Safety/Pharmacovigilance, Regulatory Affairs, Manufacturing, and Quality.Partner with Clinical and Medical leadership to support development strategy, indication prioritization, and lifecycle planning for assigned programs.Ensure program activities support regulatory milestones including INDs, protocol amendments, global health authority interactions, and potential BLA/MAA submissions.Partner with Clinical Operations to proactively identify enrollment, operational, and site-performance risks and implement mitigation strategies.Ensure seamless coordination between clinical and CMC activities supporting cell therapy manufacturing, supply planning, patient scheduling, and treatment logistics.Facilitate governance meetings, cross-functional team meetings, and executive program reviews.Collaborate with Clinical Research Scientists and Medical Directors on protocol strategy, clinical endpoints, efficacy measures, biomarkers, and patient-reported outcomes relevant to autoimmune studies.Support competitive intelligence activities and maintain awareness of evolving autoimmune treatment landscapes, clinical trial designs, and emerging therapies.Partner with Regulatory and Medical Writing teams to support preparation of briefing documents, regulatory submissions, investigator brochures, and clinical study reports.Establish and maintain program dashboards, KPIs, risk registers, and governance frameworks to ensure transparency and accountability.Drive continuous improvement of program management processes, tools, and reporting capabilities.Support budget forecasting, scenario planning, and resource prioritization across clinical programs.Mentor and develop program management staff and contribute to building scalable development operations infrastructure.QualificationsA minimum of a BA/BS and 15+ yrs in a Program/Project management supporting drug development is required, and an advanced degree (Ph.D., MS, MD) and/or PM Certification is preferred.Exceptional communication skills (in person and written word) and the ability to interact with a diverse group of individuals.Extensive experience managing and partnering with Contract Development and Manufacturing Organizations in the Cell and Gene Therapy space. Must have experience working on the sponsor side in Cell and Gene Therapy organizations; prior experience on the supplier side is considered a strong plus. Experience with gene or cell therapy development programs required.Experience applying the principles, concepts, practices, and standards of project management for dru