Manager, Commercial Operations

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions.Position SummaryThe Manager of Commercial Operations will help scale Karius’ commercial organization by building and optimizing processes, systems, and data infrastructure that improve performance and enable cross-functional execution. This role serves as a strategic and operational partner to Sales Leadership, Customer Success, Marketing, Finance, and Lab/Operations teams by translating business needs into actionable insights, scalable workflows, and governed execution across the commercial lifecycle. This role will own the operating rhythm for key commercial processes (pipeline hygiene, forecasting, deal support, reporting, and data governance), ensuring high-quality outputs that are stakeholder-ready and drive measurable impact.Why Should You Join Us?Karius aims to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company’s platform is already delivering unprecedented insights into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood, and helping industry accelerate the development of therapeutic solutions. The products Karius offers today are some of the most advanced solutions available to physicians who aim to deliver better care to many otherwise ineffectively treated patients. Our tests are the result of some incredible work done by our scientists, statisticians, engineers, and physicians, all driven by the same mission. You, as part of the Karius team, will be able to see how directly your work has a life-changing impact on people, and at scale.Reports to: Senior Director, Commercial Operations and Customer SuccessLocation: Redwood City, CA (Hybrid) or Remote (USA)Primary ResponsibilitiesCommercial Systems, Process Improvement, and GovernanceLead improvements to commercial processes and workflows across the go-to-market lifecycle (lead-to-opportunity-to-order-to-cash), ensuring clarity, consistency, and adoption. Partner with stakeholders to identify process gaps, define requirements, and deliver scalable solutions across CRM (Salesforce), marketing systems (HubSpot), and downstream integrations. Maintain governance of commercial master data (accounts, contacts, territories, referring institutions, attribution rules, etc.), including documentation and quality controls. Build and maintain process documentation, SOPs, and training materials to ensure consistency and enablement. Intake, Ticketing, and Service Delivery (Operating Standards)Own the Commercial Ops intake and ticketing process (e.g., JIRA/other), including required fields, prioritization, assignment, and closure standards. Maintain clear SLAs (e.g., 48-hour response/turnaround where applicable), proactively communicating risks, dependencies, and timeline changes before deadlines slip. Maintain a transparent tracker/backlog for all workstreams and requests, including priority, owner, due date, dependencies, and next steps. Forecasting, Pipeline Management, and Performance RhythmPartner with the Commercial Operations leader to drive pipeline discipline, forecasting accuracy, and consistent inspection routines (weekly/monthly/quarterly). Support annual comp, quota/goal, and territory planning (analysis, scenarios, and execution) in partnership with the Commercial Operations leader. Own pipeline and funnel reporting, including stage definitions, conversion metrics, velocity, and leading indicators. Ensure consistent reporting definitions and governance, and maintain stakeholder trust in metrics and reporting. Reporting, Analytics, and Business InsightsDevelop and maintain dashboards and reporting that provide clear visibility into performance, pipeline, activity, and operational health. Design and develop complex queries, comprehensive reports, and analyses to facilitate fact-based business decisions. Perform business intelligence and analytics reporting to support commercial and field team initiatives. Translate analysis into decision support: succinct insights, implications (“so what”), recommendations, and execution next steps with owners and timelines. Create stakeholder-ready outputs (leadership updates, summaries, dashboards, and analyses) with minimal rework required. Establish reporting definitions, QA checks, and governance to ensure accuracy and stakeholder trust Deal Support and Cross-Functional EnablementSupport deal execution and deal desk processes as